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EE Chapter 66 Anticancer Drugs and Chemotherapy Q&A (1 OF 21) Sample Questions

1. In tumor lysis mechanism, changes that occur in the body include all, EXCEPT:

A. Hyperuricemia
B. Hyperphosphatemia
C. Hypocalcemia
D. Hyperkalemia
E. Hypoglycemia

Ans: E

Tips: Tumor lysis syndrome (TLS) (product of excess cell lysis resulting in hyperuricemia, hyperkalemia, hypocalcemia, hyperphosphatemia, which can lead to renal failure, cardiac arrhythmias and seizures) (within hours to days).

Strategic thinking:
1. Read the question. You are asked for a metabolic abnormality that is not seen in TLS.
2. To answer this question rationally, understand TLS results from chemotherapy. Tumor cells are killed at the same time and the body cannot cope fast enough to get rid of the contents that include the important ions, released by the dying cells thereby these accumulate in the bloodstream. Your knowledge of the abundant extra and intracellular ions will be of assistance hand-in-hand. Potassium and phosphates predominate intracellularly so when the cells die, these are released together with the uric acid from nucleic acid breakdown. Calcium drops down as a result of hypophosphatemia.
3. Thus, your match is E.

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