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Chapter 78 Pharmacy Dosage Calculations Sample Questions

1. In the International System of Units (SI), most drugs levels are to be reported in the units of micromoles/litre (µmols/L). The therapeutic concentration range for theophylline (MW 180) is 10-20 µg/mL. The SI equivalent would be:

A. 0.055- 0.11 µmol/L
B. 27-55 µmol/L
C. 55-110 µmol/L
D. 110-220 µmol/L

Answer

Ans: C

Tips:
i. Careful!!! Theophylline therapeutic concentration is given in µmol/mL, while answers are given in µmol/L.
ii. Convert therapeutic concentration to µg/L: 10-20 µmol/mL = 10,000 – 20,000 µg/L
iii. Lower parameter: 10 µg/mol = 10,000 µg/L = 10,000/180 = 55 µmol/L
iv. Upper parameter: 20 µg/mL = 20,000 µg/L = 20,000/180 = 111µmol/L

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