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Chapter 58 Spectrum of Antibiotics used in Infectious Diseases Sample Questions

1. MP is a 73-year-old woman hospitalized due to shortness of breath, fatigue and weakness. She has Type 2 Diabetes Mellitus (T2DM) with a recent renal clearance of 55 ml/min. MP just recently had ischemic stroke. Upon assessement at the hospital, doctor confirmed penumonia. She is allergic to penicillin. What is the drug of choice?

A. Amoxiclav + Azithromycin
B. Levofloxacin 500 mg for 10 d
C. Moxifloxacin 400 mg q24h IV for 7 to 14 days
D. Levofloxacin 750 mg for 5 d

Answer

Ans: C

Tips: RxTx/CTC. Pneumonia. Only few fluoroquinolones have indication to respiratory infections. Levofloxacin is ≥75% renally eliminated. On the other hand, Moxifloxacin is <50% renally eliminated thus, it is safer to use in patients with renal impairment. Although Ciprofloxacin can be used, it is not a first line choice because of high resistance with S. pneumoniae.

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