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Chapter 42 Chronic Kidney Disease and Drugs in Renal Diseases Sample Questions

1. A patient has diabetes, hypertension and chronic renal failure. Creatinine clearance is 6.8 ml/min and developed seizures. Which of the following anticonvulsants would require dosage adjustment in this patient?

A. Gabapentin, Topiramate
B. Lamotrigine, Felbamate
C. Phenobarbital and Gabapentin
D. Phenytoin and Valproic acid

Answer

Ans: A

Tips: Due to the primarily renal excretion of GABAPENTIN, the following dosage adjustments are recommended for elderly patients with declining renal function, patients with renal impairment and patients undergoing hemodialysis. Because NEURONTIN is eliminated solely by renal excretion, dosage adjustments are recommended for patients with renal impairment (including elderly patients with declining renal function) and patients undergoing hemodialysis.

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