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Chapter 27 – Peripheral Vascular Disease (QE) Sample Questions

1. A patient requires an oral anticoagulant but expresses a strong preference for once-daily dosing and wishes to avoid any requirements regarding food intake for drug absorption. Which Direct Oral Anticoagulant (DOAC) best fits these criteria?

A. Dabigatran
B. Edoxaban
C. Rivaroxaban
D. Apixaban

Answer

Ans: B

• Tips: Edoxaban is dosed once daily and can be taken with or without food, unlike rivaroxaban which requires food for higher doses.
• Dabigatran requires twice-daily (BID) dosing, which does not meet the patient's request for once-daily administration.
• Rivaroxaban doses of 15 mg and 20 mg must be taken with food to ensure adequate absorption.
• Apixaban is dosed twice daily (BID), failing the once-daily requirement.

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