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Chapter 16 – Contraception (QE) Sample Questions

1. Case : Acne Exacerbation in a Woman on Oral Contraceptives. A 24-year-old woman with a history of gout is taking a combined oral contraceptive (COC) containing levonorgestrel/ethinyl estradiol. She has not used any acne medications for over a year. Recently, she developed worsening inflammatory acne, with multiple papules and pustules. Which factor is most likely contributing to the aggravation of her acne?
  1. A. NSAID use
  2. B. Allopurinol
  3. C. Levonorgestrel/ethinyl estradiol
  4. D. Gender
Answer
Ans: C
Rationale:
Levonorgestrel is a progestin with androgenic activity, which can worsen acne by increasing sebaceous gland activity.
• NSAIDs and allopurinol do not exacerbate acne.
• Gender is a risk factor but does not explain an acute worsening in this scenario.
COCs containing antiandrogenic progestins (e.g., drospirenone) are preferred for acne.
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