Pharmacy PREP Letter Vol. 1, No. 1, 2014

[prepadmin]

Content:

1) The highest suicidal risk to least suicidal risk side effects of antidepressants.

Use of paroxetine was banned by the British Regulatory Agency in 2003 for the treatment of depression in adolescents due to increased suicidality in adolescent. Later FDA has issued block box warning about the use of paroxetine and need of monitoring SSRI therapy in pediatric patients. Currently fluoxetine, fluvoxamine and sertraline..........For details signup PharmacyPREP Letter.

 

2) Comparison of drugs and factors that increase myopathies associated with statins. The most to least?

 

Statin induced myopathy

 

Step 1: characteristic of symptoms often bilateral or symmetrical, aching pain muscles as group, and muscle weakness (NO JOINT PAINS)

 

Step 2; Onset of symptoms typically weeks to few months

 

Step 3: Risk factors such as DIs (fibrates, CYP 3A4 Inh). Dose of statins and patient factor like > 65 yrs. Statins increase blood sugar.

 

Step 4: Lab tests CK-MM